![]() The process of harvesting is quite simple and can be performed as an outpatient and/or potentially on the farm. Treatment with IRAP utilizes progressive gene therapy to combat osteoarthritis in your horse. The system has been designed to stimulate the horses’ own white blood cells to produce anti-inflammatory mediators and enzymes, specifically Interleukin 1 receptor antagonist protein ( IRAP), which can reduce the inflammation present as a result of degenerative joint disease. IRAP is an anti-inflammatory protein that counteracts the destructive effects of inflammatory proteins such as Interleukin-1 (IL-1) that are produced within inflamed or arthritic joints. The product was originally developed in Europe, and has been used extensively in Germany. The post Irap: How The Horse Got His Name, And What The Letters Stand For appeared first on Horse Racing News | Paulick Report.IRAP is a new and effective intra-articular treatment for joint disease marketed by Arthrex VetSystems in the USA. “The good news is as you continue to reduce the amount of interleukin in the joint, the thing that destroys joint lining, joint cartilage is less and less, so all the destructive things that come with inflammation are reduced.” “As our industry is becoming more and more interested in the kinds of drugs we put in the body, this option is generated by the blood so it's more holistic and maybe a little bit more natural. “It is just another option for controlling inflammation in a joint in horses that actively perform,” said Peloso. IRAP has the advantage of being free from the side effects that can come with intra-articular corticosteroid injections, and there are no concerns that IRAP will spike a post-race drug test. Horses typically get a reduced work schedule for the first week after administration and can then return to full training while getting the subsequent doses, spaced a week apart. Peloso said the price for IRAP runs about $1,000 for four to six syringes gathered from one blood collection, which means it's not often a veterinarian's first call for treating arthritis. Now, about 12 years into its use in the United States, Peloso said the veterinary community has a broader understanding of it because it has been used safely on so many cases of arthritis from different types of equine athletes. ![]() IRAP and similar therapies are new to horses, relatively speaking, and it took some time for veterinarians to learn what type of therapy was most effective for which conditions. Interleukin is part of the natural inflammatory reaction that comes along with osteoarthritis, but it can have a damaging effect on the cartilage and joint capsule, worsening the joint's long-term health. “It effectively blocks the action of the thing that causes arthritis,” said Peloso. John Peloso, surgeon and owner at the Equine Medical Center of Ocala in Florida. IRAP has proven most useful for calming and staving off osteoarthritis in joints, according to Dr. Like stem cell and PRP, the goal of IRAP is to flood an injured area with a higher concentration of the healing agent, more quickly than the body would on its own. The active ingredient blocks the inflammation process that comes along with an injury. Then, the sample is spun and separated, and the IRAP is put into the injured area via injection. Blood is collected and left to incubate in syringes containing coated glass beads, which help stimulate the production of IRAP from the white blood cells in the sample. Like platelet-rich plasma and stem cell therapy, IRAP (which is confusingly, both the name of the therapy and its active ingredient) uses a component of the horse's own blood. The owner heard about it, and said, ‘That's what we'll name the horse,'” said Mora. He came back to the O'Neill barn with the Tiznow colt and the first horse's shipping sheet, saying, ‘I have the IRAP horse on the van.' The O'Neill team figured out what had happened, but “The IRAP horse” stuck. The first horse didn't have a registered name, so the driver had simply written ‘IRAP' so he could make sure the farm knew that horse needed treatment. ![]() Then, he was asked to pick up the Tiznow colt from the farm and bring him to the O'Neill barn, but the driver forgot to turn in his shipping information sheet from the first horse. Mora explained that a van driver was asked to bring one horse from the O'Neill barn to a nearby farm for some time off and some IRAP therapy.
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